Xanthine oxidase inhibitory properties of Czech medicinal plants.
Identifieur interne : 003049 ( Main/Exploration ); précédent : 003048; suivant : 003050Xanthine oxidase inhibitory properties of Czech medicinal plants.
Auteurs : Jaroslav Havlik [République tchèque] ; Raquel Gonzalez De La Huebra ; Katerina Hejtmankova ; Javier Fernandez ; Jitka Simonova ; Martin Melich ; Vojtech RadaSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2010.
Descripteurs français
- KwdFr :
- Antienzymes (pharmacologie), Betula (métabolisme), Ethnopharmacologie (MeSH), Extraits de plantes (pharmacologie), Flavonoïdes (analyse), Flavonoïdes (pharmacologie), Phénols (analyse), Phénols (pharmacologie), Plantes médicinales (MeSH), Polyphénols (MeSH), Populus (MeSH), République tchèque (MeSH), Xanthine oxidase (antagonistes et inhibiteurs).
- MESH :
- analyse : Flavonoïdes, Phénols.
- antagonistes et inhibiteurs : Xanthine oxidase.
- métabolisme : Betula.
- pharmacologie : Antienzymes, Extraits de plantes, Flavonoïdes, Phénols.
- Ethnopharmacologie, Plantes médicinales, Polyphénols, Populus, République tchèque.
- Wicri :
- geographic : République tchèque.
English descriptors
- KwdEn :
- Betula (metabolism), Czech Republic (MeSH), Enzyme Inhibitors (pharmacology), Ethnopharmacology (MeSH), Flavonoids (analysis), Flavonoids (pharmacology), Phenols (analysis), Phenols (pharmacology), Plant Extracts (pharmacology), Plants, Medicinal (MeSH), Polyphenols (MeSH), Populus (MeSH), Xanthine Oxidase (antagonists & inhibitors).
- MESH :
- chemical , analysis : Flavonoids, Phenols.
- chemical , antagonists & inhibitors : Xanthine Oxidase.
- chemical , pharmacology : Enzyme Inhibitors, Flavonoids, Phenols, Plant Extracts.
- geographic : Czech Republic, Polyphenols.
- metabolism : Betula.
- Ethnopharmacology, Plants, Medicinal, Populus.
Abstract
AIM OF THE STUDY
To investigate in vitro xanthine oxidase inhibitory properties of plants traditionally used in Czech Republic and Central-East Europe region for gout, arthritis or rheumatism treatment.
MATERIALS AND METHODS
Methylene chloride-methanolic and two ethanolic extracts of 27 plant species were screened for in vitro xanthine oxidase inhibitory activity using a spectrophotometric method.
RESULTS
Around 50% of the species exhibited some degree of xanthine oxidase inhibitory properties at 200 μg/mL, showing a moderate correlation (r=0.59) with total phenol content. The most active were methylene chloride-methanolic extracts of Populus nigra and Betula pendula, with IC(50) of 8.3 and 25.9 μg/mL, respectively, followed by 80% ethanolic extract of Caryophyllus aromaticus and Hypericum perforatum, both under 50 μg/mL.
CONCLUSIONS
Populus nigra and Betula pendula were identified as species with the highest xanthine oxidase inhibitory potential in our study. This correlates with the ethnobotanical data on their use in Central European folklore and provides the basis for further investigation on these plants.
DOI: 10.1016/j.jep.2010.08.044
PubMed: 20800669
Affiliations:
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sortKey="Hejtmankova, Katerina" sort="Hejtmankova, Katerina" uniqKey="Hejtmankova K" first="Katerina" last="Hejtmankova">Katerina Hejtmankova</name></author><author><name sortKey="Fernandez, Javier" sort="Fernandez, Javier" uniqKey="Fernandez J" first="Javier" last="Fernandez">Javier Fernandez</name></author><author><name sortKey="Simonova, Jitka" sort="Simonova, Jitka" uniqKey="Simonova J" first="Jitka" last="Simonova">Jitka Simonova</name></author><author><name sortKey="Melich, Martin" sort="Melich, Martin" uniqKey="Melich M" first="Martin" last="Melich">Martin Melich</name></author><author><name sortKey="Rada, Vojtech" sort="Rada, Vojtech" uniqKey="Rada V" first="Vojtech" last="Rada">Vojtech Rada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20800669</idno><idno type="pmid">20800669</idno><idno type="doi">10.1016/j.jep.2010.08.044</idno><idno type="wicri:Area/Main/Corpus">003083</idno><idno 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6</wicri:regionArea><wicri:noRegion>CZ-165 21 Prague 6</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez De La Huebra, Raquel" sort="Gonzalez De La Huebra, Raquel" uniqKey="Gonzalez De La Huebra R" first="Raquel" last="Gonzalez De La Huebra">Raquel Gonzalez De La Huebra</name></author><author><name sortKey="Hejtmankova, Katerina" sort="Hejtmankova, Katerina" uniqKey="Hejtmankova K" first="Katerina" last="Hejtmankova">Katerina Hejtmankova</name></author><author><name sortKey="Fernandez, Javier" sort="Fernandez, Javier" uniqKey="Fernandez J" first="Javier" last="Fernandez">Javier Fernandez</name></author><author><name sortKey="Simonova, Jitka" sort="Simonova, Jitka" uniqKey="Simonova J" first="Jitka" last="Simonova">Jitka Simonova</name></author><author><name sortKey="Melich, Martin" sort="Melich, Martin" uniqKey="Melich M" first="Martin" last="Melich">Martin Melich</name></author><author><name sortKey="Rada, Vojtech" sort="Rada, Vojtech" uniqKey="Rada V" first="Vojtech" last="Rada">Vojtech Rada</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betula (metabolism)</term><term>Czech Republic (MeSH)</term><term>Enzyme Inhibitors (pharmacology)</term><term>Ethnopharmacology (MeSH)</term><term>Flavonoids (analysis)</term><term>Flavonoids (pharmacology)</term><term>Phenols (analysis)</term><term>Phenols (pharmacology)</term><term>Plant Extracts (pharmacology)</term><term>Plants, Medicinal (MeSH)</term><term>Polyphenols (MeSH)</term><term>Populus (MeSH)</term><term>Xanthine Oxidase (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antienzymes (pharmacologie)</term><term>Betula (métabolisme)</term><term>Ethnopharmacologie (MeSH)</term><term>Extraits de 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tchèque</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIM OF THE STUDY</b></p><p>To investigate in vitro xanthine oxidase inhibitory properties of plants traditionally used in Czech Republic and Central-East Europe region for gout, arthritis or rheumatism treatment.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b></p><p>Methylene chloride-methanolic and two ethanolic extracts of 27 plant species were screened for in vitro xanthine oxidase inhibitory activity using a spectrophotometric method.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Around 50% of the species exhibited some degree of xanthine oxidase inhibitory properties at 200 μg/mL, showing a moderate correlation (r=0.59) with total phenol content. The most active were methylene chloride-methanolic extracts of Populus nigra and Betula pendula, with IC(50) of 8.3 and 25.9 μg/mL, respectively, followed by 80% ethanolic extract of Caryophyllus aromaticus and Hypericum perforatum, both under 50 μg/mL.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Populus nigra and Betula pendula were identified as species with the highest xanthine oxidase inhibitory potential in our study. This correlates with the ethnobotanical data on their use in Central European folklore and provides the basis for further investigation on these plants.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20800669</PMID><DateCompleted><Year>2011</Year><Month>05</Month><Day>11</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>132</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Nov</Month><Day>11</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Xanthine oxidase inhibitory properties of Czech medicinal plants.</ArticleTitle><Pagination><MedlinePgn>461-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2010.08.044</ELocationID><Abstract><AbstractText Label="AIM OF THE STUDY" NlmCategory="OBJECTIVE">To investigate in vitro xanthine oxidase inhibitory properties of plants traditionally used in Czech Republic and Central-East Europe region for gout, arthritis or rheumatism treatment.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Methylene chloride-methanolic and two ethanolic extracts of 27 plant species were screened for in vitro xanthine oxidase inhibitory activity using a spectrophotometric method.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Around 50% of the species exhibited some degree of xanthine oxidase inhibitory properties at 200 μg/mL, showing a moderate correlation (r=0.59) with total phenol content. The most active were methylene chloride-methanolic extracts of Populus nigra and Betula pendula, with IC(50) of 8.3 and 25.9 μg/mL, respectively, followed by 80% ethanolic extract of Caryophyllus aromaticus and Hypericum perforatum, both under 50 μg/mL.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Populus nigra and Betula pendula were identified as species with the highest xanthine oxidase inhibitory potential in our study. This correlates with the ethnobotanical data on their use in Central European folklore and provides the basis for further investigation on these plants.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Havlik</LastName><ForeName>Jaroslav</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, CZ-165 21 Prague 6, Czech Republic. havlik@af.czu.cz</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzalez de la Huebra</LastName><ForeName>Raquel</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Hejtmankova</LastName><ForeName>Katerina</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Simonova</LastName><ForeName>Jitka</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Melich</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author 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sort="Melich, Martin" uniqKey="Melich M" first="Martin" last="Melich">Martin Melich</name><name sortKey="Rada, Vojtech" sort="Rada, Vojtech" uniqKey="Rada V" first="Vojtech" last="Rada">Vojtech Rada</name><name sortKey="Simonova, Jitka" sort="Simonova, Jitka" uniqKey="Simonova J" first="Jitka" last="Simonova">Jitka Simonova</name></noCountry><country name="République tchèque"><noRegion><name sortKey="Havlik, Jaroslav" sort="Havlik, Jaroslav" uniqKey="Havlik J" first="Jaroslav" last="Havlik">Jaroslav Havlik</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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